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The overall treatment effect of donanemab continued to grow throughout the trial, with the largest differences versus placebo seen at 18 months. TRAILBLAZER-ALZ 2 enrolled participants with a broader range of cognitive scores and amyloid levels than other recent trials of amyloid plaque-targeting therapies. This delay in progression meant that, on average, participants treated with donanemab had an additional 7. CDR-SB compared to those on placebo.

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